Don S, Cohen M D, Kruger R A, Winkler T A, Katz B P, Li W, Dreesen R G, Kennan N, Tarver R, Klatte E C
Department of Radiology, Indiana University Medical Center, James Whitcomb Riley Hospital for Children, Indianapolis.
Invest Radiol. 1994 May;29(5):558-63.
The feasibility of developing an animal model to simulate radiographic features of neonatal pneumothorax was investigated, and supine computed radiography (CR) and film-screen radiography (FS) images were compared.
5-Fr pigtail catheters were inserted into the right pleural space of three New Zealand white rabbits. Two CR and two FS supine images were obtained using identical technique. After serial 4-mL injections of air, one CR and one FS supine image were obtained. The images were masked and randomized, and four radiologists reviewed the images for typical signs of pneumothorax. Chest computed tomography (CT) was performed before the injection of any air and after completion of the study.
At zero-mL air volume, radiologists did not perceive a pneumothorax. As the air volume increased, the number of signs of a pneumothorax increased; there was no significant difference between CR and FS in the number of signs of pneumothorax detected at any volume. Chest CT confirmed that there was no unexplained air leak. The volume of air injected correlated with the calculated volume from the CT.
This induced, volume-controlled, animal model simulated the supine radiographic features of neonatal pneumothorax.
研究建立模拟新生儿气胸影像学特征动物模型的可行性，并比较仰卧位计算机X线摄影（CR）和屏-片摄影（FS）图像。
将5F猪尾导管插入3只新西兰白兔的右胸腔。采用相同技术获取2幅CR仰卧位图像和2幅FS仰卧位图像。在连续注入4mL空气后，再获取1幅CR仰卧位图像和1幅FS仰卧位图像。图像进行遮盖和随机分组，4名放射科医生对图像进行气胸典型征象的评估。在注入任何空气前及研究结束后进行胸部计算机断层扫描（CT）。
空气注入量为0mL时，放射科医生未发现气胸。随着空气注入量增加，气胸征象数量增多；在任何注入量下，CR和FS检测到的气胸征象数量无显著差异。胸部CT证实无不明原因的空气泄漏。注入空气量与CT计算量相关。
这种诱导性、容量控制的动物模型模拟了新生儿气胸的仰卧位影像学特征。
