McCabe E R
Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
J Bioenerg Biomembr. 1994 Jun;26(3):317-25. doi: 10.1007/BF00763103.
Complexes made up of the kinases, hexokinase and glycerol kinase, together with the outer mitochondrial membrane voltage-dependent anion channel (VDAC) protein, porin, and the inner mitochondrial membrane protein, the adenine nucleotide translocator, are involved in tumorigenesis, diabetes mellitus, and central nervous system function. Identification of these two mitochondrial membrane proteins, along with an 18 kD protein, as components of the peripheral benzodiazepine receptor, provides independent confirmation of the interaction of porin and the adenine nucleotide translocator to form functional contact sites between the inner and outer mitochondrial membranes. We suggest that these are dynamic structures, with channel conductances altered by the presence of ATP, and that ligand-mediated conformational changes in the porin-adenine nucleotide translocator complexes may be a general mechanism in signal transduction.
由激酶、己糖激酶和甘油激酶，以及线粒体外膜电压依赖性阴离子通道（VDAC）蛋白、孔蛋白和线粒体内膜蛋白腺嘌呤核苷酸转位酶组成的复合物，参与肿瘤发生、糖尿病和中枢神经系统功能。鉴定出这两种线粒体膜蛋白以及一种18 kD蛋白作为外周苯二氮䓬受体的组成成分，为孔蛋白和腺嘌呤核苷酸转位酶相互作用形成线粒体内外膜之间的功能接触位点提供了独立的证据。我们认为这些是动态结构，其通道电导会因ATP的存在而改变，并且孔蛋白 - 腺嘌呤核苷酸转位酶复合物中配体介导的构象变化可能是信号转导的一种普遍机制。
