Arpaia G, Cimminiello C, Bellone M, Aloisio M, Rossi F, Bonfardeci G
4th Department of Medecine, S. Carlo Borromeo Hospital, Milan, Italy.
Int Angiol. 1994 Mar;13(1):15-8.
The differential diagnosis of Raynaud's Phenomenon (RP) is still problematic because of the wide variety of underlying etiological possibilities. Therefore, the diagnostic screening of patients requires easily reproducible, rapid and reliable tests to find those cases of RP secondary to a connective tissue disorder. The present study of 106 consecutive RP patients was carried out by using a combination of clinical examination, biomicroscopy of fingernail folds and bulbar conjunctiva (with scoring of vascular damage), plus the assessment of antinuclear antibodies on HEP2 cells. On the basis of the reported findings, it can be concluded that patients with RP secondary to collagen disease or so suspected also show abnormalities of the conjunctival microcirculatory bed. Patients with both primary and suspected secondary RP are significantly younger at the time of first diagnosis than patients with collagen disease-associated RP.
由于潜在病因可能性的多样性，雷诺现象（RP）的鉴别诊断仍然存在问题。因此，对患者进行诊断性筛查需要易于重复、快速且可靠的检测方法，以找出继发于结缔组织疾病的RP病例。本研究对106例连续性RP患者进行了临床检查、指甲皱襞和球结膜生物显微镜检查（对血管损伤进行评分），并对HEP2细胞上的抗核抗体进行评估。根据报告结果可以得出结论，继发于胶原病或疑似继发于胶原病的RP患者也存在结膜微循环床异常。原发性和疑似继发性RP患者在首次诊断时的年龄显著低于胶原病相关性RP患者。
