Houtman P M, Kallenberg C G, Fidler V, Wouda A A
J Rheumatol. 1986 Jun;13(3):556-63.
Nailfold capillary patterns were systematically evaluated in 51 controls and 107 patients with Raynaud's phenomenon (RP) by 2 observers. Fifty patients had primary RP, 18 RP with minor signs of connective tissue disease, and 39 secondary RP (scleroderma, CREST syndrome or mixed connective tissue disease [MCTD]). Nailfolds of all 10 fingers were photographed and blindly evaluated. Qualitative and quantitative scoring of patterns was reproducible. The 4th finger showed the fewest nonevaluable photomicrographs and best distinguished primary from secondary RP. Capillary morphology in primary RP did not differ from controls. A decrease in capillary loops best distinguished primary from secondary RP. Addition of the scores for bushy patterns, extravasates, or giant loops led to better discrimination. No item allowed distinction between different connective tissue diseases. The number of enlarged loops was inversely related to the total number of capillary loops (r = 0.55; p less than 0.01).
两名观察者对51名对照者和107名雷诺现象（RP）患者的甲襞毛细血管形态进行了系统评估。50例患者为原发性RP，18例RP伴有轻微结缔组织病体征，39例为继发性RP（硬皮病、CREST综合征或混合性结缔组织病[MCTD]）。对所有10个手指的甲襞进行拍照并进行盲法评估。模式的定性和定量评分具有可重复性。无名指显示出最少的无法评估的显微照片，并且能最好地区分原发性和继发性RP。原发性RP的毛细血管形态与对照者无差异。毛细血管袢减少最能区分原发性和继发性RP。增加丛生模式、渗出物或巨大袢的评分可导致更好的区分。没有一项能区分不同的结缔组织病。增大袢的数量与毛细血管袢的总数呈负相关（r = 0.55；p < 0.01）。
