Avellone G, Di Garbo V, Cordova R, Cucinella G, De Simone R, Raneli G, Bompiani G
Institute of Clinical Medicine, University of Palermo, Italy.
Int Angiol. 1994 Mar;13(1):25-9.
Twenty obese subjects (Males = 8, Females = 12; average age = 39.5 +/- 2.5 years; B.M.I. = 36.2 +/- 2.5), 20 overweight subjects (Males = 8, Females = 12; average age = 38.5 +/- 2 years; B.M.I. = 28.8 +/- 0.4) and 20 non obese healthy subjects as controls, matched for sex and age (Males = 8, Females = 12; average age = 37.5 +/- 2 years; B.M.I. = 22.4 +/- 0.8) were selected. We determined: blood glucose, triglycerides, total cholesterol, HDL-cholesterol, Apolipoproteins A1 and B, Factor VII, fibrinogen and plasminogen. Before and after a venous occlusion test were also measured: t-PA Antigen, PAI activity and haematocrit. Metabolic, coagulative and fibrinolytic pathological changes were observed in overweight and obese subjects and the interaction of these risk factors may contribute to the pathogenesis of atherosclerosis vascular disease and to the high rate of thromboembolic events reported in obesity.
选取了20名肥胖受试者（男性8名，女性12名；平均年龄 = 39.5±2.5岁；体重指数 = 36.2±2.5）、20名超重受试者（男性8名，女性12名；平均年龄 = 38.5±2岁；体重指数 = 28.8±0.4）以及20名非肥胖健康受试者作为对照，这些对照在性别和年龄上相匹配（男性8名，女性12名；平均年龄 = 37.5±2岁；体重指数 = 22.4±0.8）。我们测定了：血糖、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、载脂蛋白A1和B、凝血因子VII、纤维蛋白原和纤溶酶原。在静脉闭塞试验前后还测量了：组织型纤溶酶原激活剂抗原、纤溶酶原激活物抑制剂活性和血细胞比容。在超重和肥胖受试者中观察到了代谢、凝血和纤溶的病理变化，这些危险因素之间的相互作用可能导致动脉粥样硬化性血管疾病的发病机制以及肥胖人群中报道较高的血栓栓塞事件发生率。
