Mehta Sachin, Farmer John A
Section of Cardiology, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Room 525 D, Houston, TX 77030, USA.
Curr Atheroscler Rep. 2007 Aug;9(2):134-8. doi: 10.1007/s11883-007-0009-4.
Obesity is a highly prevalent disease with multiple implications for cardiovascular morbidity and mortality. The traditional view of obesity is that excessive adipose tissue represents a passive storage depot of excess energy. However, obesity has been demonstrated to be a highly active endocrine organ with multiple metabolic pathways that interact with classic cardiac risk factors. The role of inflammation in atherosclerosis has been clarified by the ready availability of a variety of markers, including C-reactive protein, adiponectin, tumor necrosis factor-alpha, hemostatic markers, resistin, and a variety of emerging markers such as interleukins and adhesion molecules. Adipose tissue has been demonstrated to be the site of synthesis of a variety of proteins that are intimately involved in the regulation of inflammation. The concept that obesity represents an inflammatory state has gained credence over the past decade and has provided insights into the mechanisms of atherosclerosis and risk factor interaction.
肥胖是一种高度流行的疾病，对心血管疾病的发病率和死亡率有多种影响。传统观点认为，过多的脂肪组织是多余能量的被动储存库。然而，肥胖已被证明是一个高度活跃的内分泌器官，具有多种代谢途径，可与经典的心脏危险因素相互作用。通过多种标志物的现成可得，炎症在动脉粥样硬化中的作用已得到阐明，这些标志物包括C反应蛋白、脂联素、肿瘤坏死因子-α、止血标志物、抵抗素以及多种新兴标志物，如白细胞介素和黏附分子。脂肪组织已被证明是多种蛋白质的合成部位，这些蛋白质密切参与炎症调节。在过去十年中，肥胖代表一种炎症状态的概念已得到认可，并为动脉粥样硬化的机制和危险因素相互作用提供了见解。
