丁香油的抗血栓形成活性。

Antithrombotic activity of clove oil.

作者信息

Saeed S A, Gilani A H

机构信息

Department of Pharmacology, Aga Khan University Medical College, Karachi.

出版信息

J Pak Med Assoc. 1994 May;44(5):112-5.

PMID:8078176

Abstract

Clove oil inhibited human platelet aggregation induced by arachidonic acid (AA), platelet-activating factor (PAF) or collagen. Clove oil was a more effective inhibitor for aggregation induced by AA and PAF (IC50:4 and 6 microM respectively) than collagen (IC50: 132 microM). The in vivo experiments in rabbits showed that clove oil (50-100 mg/kg) afforded 100% protection against PAF (11 mg/kg, i.v.) and 70% protection against AA (2.0 mg/kg, i.v.)-induced thrombosis and shock due to pulmonary platelet thrombosis. It also inhibited thromboxane-A2 and 12-HETE production by human platelets incubated with [C14] AA. These results are indicative that clove oil is inhibitory of platelet aggregation and thromboxane synthesis and may act as anti-thrombotic agent.

摘要

丁香油可抑制花生四烯酸（AA）、血小板活化因子（PAF）或胶原蛋白诱导的人血小板聚集。丁香油对AA和PAF诱导的聚集（IC50分别为4和6 microM）的抑制作用比胶原蛋白（IC50为132 microM）更有效。在兔体内实验表明，丁香油（50 - 100 mg/kg）对PAF（11 mg/kg，静脉注射）诱导的血栓形成和因肺血小板血栓形成引起的休克提供100%的保护，对AA（2.0 mg/kg，静脉注射）诱导的血栓形成和休克提供70%的保护。它还抑制用[C14]AA孵育人血小板产生血栓素 - A2和12 - HETE。这些结果表明丁香油可抑制血小板聚集和血栓素合成，并可能作为抗血栓药物起作用。