Sakaguchi J, Takeshita M, Kagawa M, Izawa M, Takakura K
Department of Neurosurgery, Tokyo Women's Medical College, Japan.
Neurosurg Rev. 1994;17(1):67-71. doi: 10.1007/BF00309990.
We studied human lymphocyte antigen (HLA) types in a group of 45 patients who had aneurysmal subarachnoid hemorrhage (SAH). A significantly increased frequency of HLA antigen A31 and a significantly decreased frequency of HLA antigen B40 were found. In patients with delayed ischemic neurological deficit (DIND) following aneurysmal SAH and HLA typing, HLA-Bw60 antigen showed significant increases; in patients who did not develop HLA-Aw33 and -Cw4 antigens showed significant. Among the patients with Fisher's Group 3 on CT, in particular, these antigens significantly increased when compared with controls from the same geographic area. These results suggest that HLA-Bw60 antigen plays a role as predisposing factor of DIND resulting from vasospasm following aneurysmal SAH, and that HLA-Aw33 and -Cw4 exert protective influence against DIND.
我们对45例动脉瘤性蛛网膜下腔出血（SAH）患者的人类淋巴细胞抗原（HLA）类型进行了研究。发现HLA抗原A31的频率显著增加，而HLA抗原B40的频率显著降低。在动脉瘤性SAH及HLA分型后出现延迟性缺血性神经功能缺损（DIND）的患者中，HLA - Bw60抗原显著增加；在未发生DIND的患者中，HLA - Aw33和 - Cw4抗原显著增加。特别是在CT表现为Fisher 3级的患者中，与来自同一地理区域的对照组相比，这些抗原显著增加。这些结果表明，HLA - Bw60抗原是动脉瘤性SAH后血管痉挛导致DIND的易感因素，而HLA - Aw33和 - Cw4对DIND具有保护作用。
