Solov'ev A S
Patol Fiziol Eksp Ter. 1994 Apr-Jun(2):31-3.
The proliferative activity of splenic cells (SC) to phytohemagglutinin (PHA), concanavalin A (Con A), lipopolysaccharide (LPS), pokeweed mitogen (PWM) and alloantigens, as well as the immune response to sheep red cells (SRS) were investigated in mice undergoing hyperthermia. There was an increase in the proliferative activity of SC to mitogens and alloantigens in mice having a rectal temperature of 42 degrees C once. The thermal shock was accompanied by the suppression of proliferative responses of SB to mitogens and alloantigens in mice. There was a decreased immune response of lymphocytes to SRC in the mice. The suppression of proliferative activities of lymphocytes to mitogens and alloantigens was found at days 10-30 in mice undergoing hyperthermia (43-44 degrees C) for 20 minutes daily. There was a lower immune response to SRC in mice at days 5-20. No changes of immune responses were found on day 40 post-induction of hyperthermia in mice.
对处于热疗状态的小鼠，研究了脾细胞（SC）对植物血凝素（PHA）、刀豆蛋白A（Con A）、脂多糖（LPS）、商陆丝裂原（PWM）和同种抗原的增殖活性，以及对绵羊红细胞（SRS）的免疫反应。体温曾达到42℃的小鼠，其脾细胞对丝裂原和同种抗原的增殖活性增强。热休克伴随小鼠脾细胞对丝裂原和同种抗原增殖反应的抑制。小鼠淋巴细胞对SRC的免疫反应降低。每天进行20分钟热疗（43 - 44℃）的小鼠，在第10 - 30天发现淋巴细胞对丝裂原和同种抗原的增殖活性受到抑制。在第5 - 20天，小鼠对SRC的免疫反应较低。热疗诱导后第40天，未发现小鼠免疫反应有变化。
