Volz H P, Möller H J
Bonn University, Psychiatric Department, Germany.
Pharmacopsychiatry. 1994 May;27(3):93-100. doi: 10.1055/s-2007-1014286.
We report on the results of controlled clinical antidepressant trials with elderly depressed patients which meet certain methodological requirements and have been published since 1980. The safety, tolerability, and efficacy of the investigated compounds are reviewed. In the light of the diagnostic problems and the altered pharmacokinetic behavior in this special age group we conclude that the progress in scientific knowledge in the last 13 years has only been moderate.
我们报告了自1980年以来发表的、符合某些方法学要求的老年抑郁症患者对照临床抗抑郁试验结果。对所研究化合物的安全性、耐受性和疗效进行了综述。鉴于该特殊年龄组存在的诊断问题以及药代动力学行为的改变，我们得出结论，过去13年科学知识的进展较为有限。
