Bekpinar S, Oner P, Eryürek F G
Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, Turkey.
Prog Neuropsychopharmacol Biol Psychiatry. 1994 May;18(3):555-62. doi: 10.1016/0278-5846(94)90012-4.
The response of central cholinergic neurotransmission to the chronic administration of some psychotropic drugs to rats was investigated using brain acetylcholinesterase activity as a neurochemical marker for cholinergic neurons. Rats were divided into four groups. Three experimental groups were given chlorpromazine, amitriptyline, or diazepam respectively, for a period of 30 days; and the control group received physiological saline only. Long-term treatment of chlorpromazine and amitriptyline resulted in significant increases in rat brain cortex enzyme activity, whereas only a slight increase was observed in the diazepam-treated group. These results indicate that the chronic treatment with some psychotropic drugs causes changes in central cholinergic transmission.
以脑乙酰胆碱酯酶活性作为胆碱能神经元的神经化学标志物，研究了中枢胆碱能神经传递对大鼠长期给予某些精神药物的反应。将大鼠分为四组。三个实验组分别给予氯丙嗪、阿米替林或地西泮，为期30天；对照组仅给予生理盐水。长期给予氯丙嗪和阿米替林导致大鼠大脑皮层酶活性显著增加，而地西泮治疗组仅观察到轻微增加。这些结果表明，长期给予某些精神药物会导致中枢胆碱能传递发生变化。
