Tsukamoto T, Asakura M, Tsuneizumi T, Satoh Y, Shinozuka T, Hasegawa K
Department of Psychiatry St. Marianna University, School of Medicine, Kanagawa, Japan.
Prog Neuropsychopharmacol Biol Psychiatry. 1994 May;18(3):615-8. doi: 10.1016/0278-5846(94)90017-5.
The effects of once a day dose of sulpiride efficacy and safety was evaluated in patients with major depressive disorder. The patients received sulpiride once a day in the morning or in the evening. There were no significant differences between two groups in the mean measures of efficacy. Side effects were rare and all of a mild degree. The most common side effects were sedation, constipation, and dryness of mouth. Out of regard for the administrative and psychological advantage of the once a day dosage this form should be preferred in the treatment of major depression.
对重度抑郁症患者评估了每日一次服用舒必利的疗效和安全性。患者于早晨或晚上每日一次服用舒必利。两组在疗效平均测量指标上无显著差异。副作用少见且均为轻度。最常见的副作用是镇静、便秘和口干。出于对每日一次给药方式在管理和心理方面优势的考虑，这种剂型在重度抑郁症治疗中应优先选用。
