Furness G, Whitescarver J
Proc Soc Exp Biol Med. 1975 Jun;149(2):427-32. doi: 10.3181/00379727-149-38821.
During attempts to eliminate Mycoplasma hominis from a monkey kidney BSC-1 cell line with antibiotics, the mycoplasmas were isolated repeatedly. However, the organisms ultimately failed to grow on medium although electron microscopy confirmed that the cell culture still contained mycoplasmas. Thus, the mycoplasma had adapted to an environment in which viable cells were required for growth. Budding mycoplasmas which are indicative of replication were seen associated with viable cells extracellularly. Moreover, structures resembling cycoplasmas were observed budding from the cells which suggests that the mycoplasmas replicate within the cells and are similar to many viruses in their manner of release from the cells.
在用抗生素从猴肾BSC - 1细胞系中清除人型支原体的过程中，支原体被反复分离出来。然而，尽管电子显微镜证实细胞培养物中仍含有支原体，但这些微生物最终未能在培养基上生长。因此，支原体已经适应了一种需要活细胞才能生长的环境。在细胞外可见与活细胞相关的出芽支原体，这表明正在进行复制。此外，观察到从细胞中出芽的类似支原体的结构，这表明支原体在细胞内进行复制，并且在从细胞中释放的方式上与许多病毒相似。
