蜡样芽孢杆菌鞘磷脂酶（一种细菌溶血素）对神经生长因子诱导的PC12细胞神经突生长的抑制作用。
Inhibition of NGF-induced neurite outgrowth of PC12 cells by Bacillus cereus sphingomyelinase, a bacterial hemolysin.
作者信息
Tamura H, Noto M, Kinoshita K, Ohkuma S, Ikezawa H
机构信息
Department of Microbial Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
出版信息
Toxicon. 1994 May;32(5):629-33. doi: 10.1016/0041-0101(94)90211-9.
Sphingomyelinase of Bacillus cereus, a bacterial hemolysin, reduced nerve growth factor (NGF)-induced neurite outgrowth of PC12 cells in a dose-dependent manner. At 200 mU/ml, sphingomyelinase repressed half the neurite outgrowth of the cells at 250 ng/ml NGF. The c-fos superinduction, one of the early responses induced by NGF, was not influenced by this treatment, suggesting that the repression by sphingomyelinase occurred via a protein kinase C-independent pathway.
蜡样芽孢杆菌的鞘磷脂酶是一种细菌溶血素，它能以剂量依赖的方式减少神经生长因子（NGF）诱导的PC12细胞的神经突生长。在200 mU/ml时，鞘磷脂酶抑制了250 ng/ml NGF条件下细胞一半的神经突生长。c-fos超诱导是NGF诱导的早期反应之一，该处理对其没有影响，这表明鞘磷脂酶的抑制作用是通过一条不依赖蛋白激酶C的途径发生的。
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