Eliseeva Iu E, Pavlikhina L V, Shavgulidze T V, Messina E, Dzhakonello A, Salerno K, Perrikone R
Vopr Med Khim. 1994 May-Jun;40(3):35-7.
An endogenous activator of the angiotensin-converting enzyme (ACE), unknown earlier, was detected in freshly prepared human neutrophils. Supernatants of the neutrophil suspension produced a 1.6-2-fold activation of the ACE isolated from bovine kidney cortex. The ACE activating effect of these supernatants correlated with concentration of neutrophils in the initial suspension. The activator did not penetrate through membranes of Centricon-30. This activator was also found in blood serum of patients with hereditary deficiency of the complement CI-esterase inhibitor. The neutrophil-released ACE activator is likely to be involved in the modulation of inflammatory responses.
在新鲜制备的人中性粒细胞中检测到一种此前未知的血管紧张素转换酶（ACE）内源性激活剂。中性粒细胞悬液的上清液可使从牛肾皮质分离的ACE激活1.6至2倍。这些上清液对ACE的激活作用与初始悬液中中性粒细胞的浓度相关。该激活剂不能穿透Centricon - 30的膜。在遗传性补体C1酯酶抑制剂缺乏患者的血清中也发现了这种激活剂。中性粒细胞释放的ACE激活剂可能参与炎症反应的调节。
