Pavlikhina L V, Shavghulidze T V, Messina E, Giacomello A, Salerno C, Perricone R
Institute of Biological and Medical Chemistry, Russian Academy of Medical Sciences, Moscow.
Biochem Mol Biol Int. 1993 Jul;30(4):665-73.
An endogenous ACE activator has been revealed. Neutrophil-enriched human leucocyte preparations released in isotonic media a relatively thermostable factor, capable of increasing the angiotensin-converting enzyme activity 1.6-2.0-fold. Activator would not pass through a 30 kDa cutoff membrane. Data on the presence of the activator in vivo were obtained in studies of protein-free serum fractions of patients with a hereditary CI-esterase inhibitor deficiency. It was suggested that the neutrophil-released ACE activator could have a role in the modulation of the inflammatory response.
一种内源性血管紧张素转换酶（ACE）激活剂已被发现。富含中性粒细胞的人白细胞制剂在等渗介质中释放出一种相对耐热的因子，能够使血管紧张素转换酶活性增加1.6至2.0倍。该激活剂不能通过截留分子量为30 kDa的膜。通过对遗传性C1酯酶抑制剂缺乏患者的无蛋白血清组分进行研究，获得了该激活剂在体内存在的数据。有人提出，中性粒细胞释放的ACE激活剂可能在炎症反应的调节中发挥作用。
