Platz-Christensen J J, Sundström E, Larsson P G
Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Göteborg, Sweden.
Acta Obstet Gynecol Scand. 1994 Aug;73(7):586-8. doi: 10.3109/00016349409006278.
In an attempt to investigate an association between the finding of clue cells in Papanicolaou-stained (PAP) smears and cervical intraepithelial neoplasia (CIN), a total of 6150 smears from 1976 were re-investigated.
Clue cells representing bacterial vaginosis were present in 10% of the PAP-smears. CIN II and III alone, as well as all CIN cases, were more common in women with bacterial vaginosis (p < 0.001). Histologically CIN III/carcinoma in situ was found in nine patients with and in 16 patients without bacterial vaginosis. The relative risk of having CIN III/carcinoma in situ if the women had bacterial vaginosis was 5.0 with 95% confidence interval of 2.2-11.6.
The possibility exists that bacterial vaginosis is in some way associated with the development of cervical intraepithelial neoplasia, i.e. as a cofactor to human papilloma virus. Therefore, bacterial vaginosis must be taken in consideration in future studies on CIN.
为了研究巴氏染色涂片检查中线索细胞的发现与宫颈上皮内瘤变（CIN）之间的关联，对1976年的6150份涂片进行了重新检查。
10%的巴氏涂片存在代表细菌性阴道病的线索细胞。仅CIN II和III以及所有CIN病例在患有细菌性阴道病的女性中更为常见（p < 0.001）。组织学上，9例患有细菌性阴道病的患者和16例没有细菌性阴道病的患者发现了CIN III/原位癌。如果女性患有细菌性阴道病，发生CIN III/原位癌的相对风险为5.0，95%置信区间为2.2 - 11.6。
细菌性阴道病可能在某种程度上与宫颈上皮内瘤变的发生有关，即作为人乳头瘤病毒的一个辅助因素。因此，在未来关于CIN的研究中必须考虑细菌性阴道病。
