Huang Yu, Wu Xinzhi, Lin Ying, Li Wenzhou, Liu Jiahua, Song Baozhi
Department of Obstetrics and Gynecology, Shengli Clinical Medical College of Fujian Medical University and Fujian Provincial Hospital, Fuzhou, Fujian 350001, P.R. China.
Department of Pathology, Shengli Clinical Medical College of Fujian Medical University and Fujian Provincial Hospital, Fuzhou, Fujian 350001, P.R. China.
Oncol Lett. 2020 Aug;20(2):1915-1921. doi: 10.3892/ol.2020.11738. Epub 2020 Jun 16.
There is an indirect link between multiple sexual partners (MSP) and cervical intraepithelial neoplasia (CIN) or even cervical cancer (CC). MSP may also lead to bacterial vaginosis (BV). The relationship among MSP, BV, human papillomavirus (HPV) infection and CIN/CC development in Chinese women remains unclear. The present study was designed to clarify their association. The study retrospectively analyzed 549 female patients who had visited a physical examination center. The MSP information was acquired, and vaginal microecology, HPV and cervical conization pathology (CCP) tests were performed when necessary. MSP status was distinct among patients with different levels of BV severity. In addition, as the severity of BV progressed, the HPV-positive ratio increased. Meanwhile, MSP was significantly associated with a positive HPV outcome, including HPV 16, HPV 18 and other high-risk HPV infections. The MSP group had a significantly higher percentage of positive CCP outcomes (particularly cases with CIN-II and CIN-III). Similarly, higher BV severity meant more severe CIN/CC progression. A logistic regression model based on age, MSP status and the Nugent score level was used in order to predict the CCP outcome. Furthermore, a receiver operating characteristic curve analysis resulted in an area under the curve of 0.834. In conclusion, the combination of MSP information and BV examination may provide a rapid, economic and accurate prediction of CIN/CC. Health education on sexual behavior and timely detection/treatment of BV should be conducted to reduce the risk of CC.
多个性伴侣（MSP）与宫颈上皮内瘤变（CIN）甚至宫颈癌（CC）之间存在间接联系。MSP还可能导致细菌性阴道病（BV）。中国女性中MSP、BV、人乳头瘤病毒（HPV）感染与CIN/CC发生之间的关系仍不清楚。本研究旨在阐明它们之间的关联。该研究回顾性分析了549名到体检中心就诊的女性患者。获取了MSP信息，并在必要时进行了阴道微生态、HPV和宫颈锥切病理（CCP）检查。不同BV严重程度的患者中MSP状况不同。此外，随着BV严重程度的进展，HPV阳性率增加。同时，MSP与HPV阳性结果显著相关，包括HPV 16、HPV 18和其他高危HPV感染。MSP组CCP阳性结果的百分比显著更高（尤其是CIN-II和CIN-III病例）。同样，BV严重程度越高意味着CIN/CC进展越严重。使用基于年龄、MSP状况和Nugent评分水平的逻辑回归模型来预测CCP结果。此外，受试者工作特征曲线分析得出曲线下面积为0.834。总之，MSP信息与BV检查相结合可能为CIN/CC提供快速、经济且准确的预测。应开展关于性行为的健康教育并及时检测/治疗BV以降低CC风险。
