大脑皮质毛细血管网络中的红细胞流动异质性。

Erythrocyte flow heterogeneity in the cerebrocortical capillary network.

作者信息

Hudetz A G, Fehér G, Knuese D E, Kampine J P

机构信息

Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.

出版信息

Adv Exp Med Biol. 1994;345:633-42. doi: 10.1007/978-1-4615-2468-7_84.

DOI:10.1007/978-1-4615-2468-7_84

PMID:8079767

Abstract

The heterogeneity of erythrocyte flow velocity and erythrocyte flux and their dependence on decreased cerebral perfusion pressure were studied in the rat cerebral cortex using intravital video microscopy. With decreased perfusion pressure, both mean and range of erythrocyte flow velocity of individual capillaries was reduced. Both cell velocity and cell flux decreased more in high flow capillaries than in low flow capillaries. The results are compatible with the hypothesis that redistribution of capillary flow during hypotension may help to maintain the perfusion of arterio-venous capillary flow pathways. Although the data are preliminary, they represent the first direct measurements of capillary flow path length and transit time in the capillary network of the cerebral cortex.

摘要

利用活体视频显微镜技术，在大鼠大脑皮层中研究了红细胞流速和红细胞通量的异质性及其对脑灌注压降低的依赖性。随着灌注压降低，单个毛细血管中红细胞流速的平均值和范围均减小。高流速毛细血管中的细胞速度和细胞通量比低流速毛细血管中的下降得更多。这些结果与以下假设相符：低血压期间毛细血管血流的重新分布可能有助于维持动静脉毛细血管血流途径的灌注。尽管数据是初步的，但它们代表了对大脑皮层毛细血管网络中毛细血管血流路径长度和通过时间的首次直接测量。