Lee Jonghwan, Wu Weicheng, Boas David A
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
J Cereb Blood Flow Metab. 2016 Feb;36(2):375-80. doi: 10.1177/0271678X15605851. Epub 2015 Sep 30.
This Brief Communication reports early homogenization of capillary network flow during somatosensory activation in the rat cerebral cortex. We used optical coherence tomography and statistical intensity variation analysis for tracing changes in the red blood cell flux over hundreds of capillaries nearly at the same time with 1-s resolution. We observed that while the mean capillary flux exhibited a typical increase during activation, the standard deviation of the capillary flux exhibited an early decrease that happened before the mean flux increase. This network-level data is consistent with the theoretical hypothesis that capillary flow homogenizes during activation to improve oxygen delivery.
本简短通讯报道了大鼠大脑皮层体感激活过程中毛细血管网络血流的早期均质化。我们使用光学相干断层扫描和统计强度变化分析,以1秒的分辨率几乎同时追踪数百条毛细血管中红细胞通量的变化。我们观察到,虽然平均毛细血管通量在激活过程中呈现典型的增加,但毛细血管通量的标准差在平均通量增加之前就出现了早期下降。这些网络层面的数据与激活过程中毛细血管血流均质化以改善氧气输送的理论假设一致。