Grogan J B, Smith G V
Surgery. 1975 Sep;78(3):316-21.
The peripheral blood neutrophils from 17 kidney transplant recipients were studied for their ability to phagocytose and kill Pseudomonas aeruginosa in vitro. Practically all of the percent phagocytosis values were within the normal range but many of the neutrophil samples demonstrated a reduced ability to kill ingested P. aeruginosa, particularly within the 3 month period immediately after transplant. Of the 17 patients studied, ten were found to have neutrophils with a reduced capacity to kill the test bacteria. These defects in bactericidal capacity were found in patients who received antihuman-lymphocyte globulin (ALG), large doses of methylprednisolone for rejection, and mostly in subclinical infection with Pseudomonas or other gram-negative bacterial species.
对17名肾移植受者的外周血中性粒细胞进行了研究，以评估其体外吞噬和杀灭铜绿假单胞菌的能力。几乎所有的吞噬百分比值都在正常范围内，但许多中性粒细胞样本显示出杀灭摄入的铜绿假单胞菌的能力下降，特别是在移植后的3个月内。在研究的17名患者中，发现有10名患者的中性粒细胞杀灭试验细菌的能力降低。这些杀菌能力缺陷见于接受抗人淋巴细胞球蛋白（ALG）、大剂量甲基强的松龙治疗排斥反应的患者，且大多见于铜绿假单胞菌或其他革兰氏阴性菌的亚临床感染患者。
