泼尼松龙和硫唑嘌呤在体内对多形核白细胞功能的影响，以及泼尼松龙、硫唑嘌呤和6-巯基嘌呤在体外对多形核白细胞功能的影响。
The effects on polymorphonuclear leucocyte function of prednisolone and azathioprine in vivo and prednisolone, azathioprine and 6-mercaptopurine in vitro.
作者信息
Losito A, Williams D G, Cooke G, Harris L
出版信息
Clin Exp Immunol. 1978 Jun;32(3):423-8.
The effects of prednisolone azathioprine and 6-mercaptopurine on polymorphonuclear neutrophil chemotaxis, phagocytosis, and killing of Staphylococcus aureus and Candida albicans have been studied. In twenty patients with a functioning kidney graft, taking both azathioprine 2.5 mg/kg/day and prednisolone (mean dose 0.59 mg/kg/day; range 0.30-1.0 mg/kg/day), the polymorphonuclear function did not significantly differ from that in either twenty-two normal or eighteen uraemic controls. Addition of prednisolone, 1.2 X 10(-5) M, azathioprine, 2.1 X 10(-5) M, and 6-mercaptopurine, 2.1 X 10(-5) M, using each drug alone, to normal human polymorphonuclear cells in vitro did not significantly alter their function. It is concluded that prednisolone and azathioprine together in vivo and that both these drugs and 6-mercaptopurine singly in vitro have no significant deleterious effect on polymorphonuclear function and do not contribute, in this way, to the increased susceptibility of patients receiving these drugs to infection.
已研究了泼尼松龙、硫唑嘌呤和6-巯基嘌呤对多形核中性粒细胞趋化性、吞噬作用以及对金黄色葡萄球菌和白色念珠菌杀伤作用的影响。在20例肾移植功能正常且每日服用硫唑嘌呤2.5mg/kg以及泼尼松龙（平均剂量0.59mg/kg/天；范围0.30 - 1.0mg/kg/天）的患者中，其多形核细胞功能与22例正常对照者或18例尿毒症对照者相比无显著差异。在体外，向正常人多形核细胞中单独加入1.2×10⁻⁵M泼尼松龙、2.1×10⁻⁵M硫唑嘌呤和2.1×10⁻⁵M 6-巯基嘌呤，并未显著改变其功能。结论是，泼尼松龙和硫唑嘌呤在体内联合应用，以及这两种药物和6-巯基嘌呤在体外单独应用，对多形核细胞功能均无显著有害影响，并且不会以此方式导致接受这些药物的患者对感染的易感性增加。
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