Ley C, Le C, Olshen E M, Reingold A L
Epidemiology Program, School of Public Health, University of California, Berkeley 94720.
JAMA. 1994 Feb 9;271(6):460-3.
To determine the reason(s) why serologic tests for Lyme disease are performed, who initiates the test requests, and how the test results are used in a clinical setting.
Retrospective cohort.
Prepaid health plan in northern California.
Consecutive sample of 117 patients for whom at least one serologic test for Lyme disease was performed during a 3-month period.
Reason for ordering and result of the serologic test, differential diagnoses, and treatment.
One of 117 patients had antibodies to Borrelia burgdorferi. Fifty-six percent of test requests were initiated by the physician and 35% by the patient. Of 66 tests ordered by the physician, 20% were performed because of suspected early Lyme disease, 6% as follow-up of a tick bite, 2% to confirm a prior history of Lyme disease, 14% as a workup for arthritis, and 60% as one of a battery of laboratory tests for vague symptoms. Of 41 tests initiated by the patient, 51% were performed because of a history of a tick bite. The reasons for ordering 10 tests were undetermined.
Only 19% of all serologic tests for Lyme disease were performed because the physician suspected Lyme disease in the patient. Particularly in light of the low probability of contracting Lyme disease in California, it appears that this serologic test is being overused. Indiscriminate testing increases health care costs and does not appear to affect treatment decisions. Education is needed regarding the limitations of this serologic test.
确定进行莱姆病血清学检测的原因、发起检测请求的人员以及检测结果在临床环境中的使用方式。
回顾性队列研究。
北加利福尼亚的预付健康计划。
在3个月期间内至少进行过一次莱姆病血清学检测的117例患者的连续样本。
检测的订购原因和血清学检测结果、鉴别诊断和治疗。
117例患者中有1例对伯氏疏螺旋体产生抗体。56%的检测请求由医生发起,35%由患者发起。在医生订购的66项检测中,20%是因为怀疑早期莱姆病而进行的,6%是作为蜱叮咬后的随访,2%是为了确认既往莱姆病病史,14%是作为关节炎的检查,60%是作为一系列针对模糊症状的实验室检测之一。在患者发起的41项检测中,51%是因为有蜱叮咬史而进行的。10项检测的订购原因未确定。
所有莱姆病血清学检测中只有19%是因为医生怀疑患者患有莱姆病而进行的。特别是考虑到在加利福尼亚感染莱姆病的可能性较低,似乎这种血清学检测被过度使用了。不加区别的检测增加了医疗成本,而且似乎并未影响治疗决策。需要就这种血清学检测的局限性进行教育。