Dzhaparidze M N, Martens L A, Egorova V D, Karaeva L T, Derteva I I
Zh Mikrobiol Epidemiol Immunobiol. 1975 Jun(6):48-51.
The authors suggest the use of determination of the titre of the diffuse precipitation in gel test with the O-cholera serum, and the content of reducing sugars after Hagedorn-Jensen to characterize the antibacterial properties of the cholerogen-toxoid preparation along with (or instead of) the active mouse protection (AU50) test used earlier, because a close correlative association was established between them. No correlative association proved to exist between the vibriocidal antibody titre of the sera of rabbits immunized with the cholerogen-toxoid and the mouse protection (AU50) test or the titre of the precipitation in gel test in the preparation.
作者建议,除了(或代替)此前使用的活性小鼠保护(AU50)试验外,采用O-霍乱血清凝胶试验中弥漫性沉淀滴度的测定以及哈格多恩-延森法测定还原糖含量,来表征霍乱类毒素制剂的抗菌特性,因为已在它们之间建立了密切的相关性联系。事实证明,用霍乱类毒素免疫的兔血清的杀弧菌抗体滴度与小鼠保护(AU50)试验或制剂凝胶试验中的沉淀滴度之间不存在相关性联系。