乳腺癌患者CA 125升高是否为胸膜转移的指标？
Is an increase in CA 125 in breast cancer patients an indicator of pleural metastases?
作者信息
Jäger W, Kissing A, Cilaci S, Melsheimer R, Lang N
机构信息
Department of Obstetrics and Gynaecology, University of Erlangen-nuremberg, Germany.
出版信息
Br J Cancer. 1994 Sep;70(3):493-5. doi: 10.1038/bjc.1994.333.
The retrospective analysis of 250 breast cancer patients with disseminated disease provided evidence that the increase in CA 125 serum levels in these patients was caused by lung metastases or pleural effusions. Seven patients with lung metastases and pleural involvement had elevated CA 125 levels, while in four patients with lung metastases but without pleural effusions CA 125 levels remained normal. In patients with only bone or liver metastases CA 125 levels were usually not elevated. If these results are confirmed, CA 125 would be the first tumour marker in breast cancer whose levels could be associated with one single site of metastases.
对250例播散性乳腺癌患者的回顾性分析表明，这些患者血清CA 125水平升高是由肺转移或胸腔积液所致。7例有肺转移和胸膜受累的患者CA 125水平升高，而4例有肺转移但无胸腔积液的患者CA 125水平仍正常。仅发生骨或肝转移的患者CA 125水平通常不升高。如果这些结果得到证实，CA 125将成为乳腺癌中首个其水平可能与单一转移部位相关的肿瘤标志物。
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