Petitto J M, Lysle D T, Gariepy J L, Lewis M H
Department of Psychiatry, University of Florida, Gainesville 32610.
Brain Behav Immun. 1994 Jun;8(2):111-22. doi: 10.1006/brbi.1994.1011.
We have recently demonstrated that selective breeding of ICR mice for differences in social behavior (i.e., high versus low levels of social isolation-induced aggression) are related to increased susceptibility to tumor development and reduced levels of natural killer (NK) cell activity. In the present investigation, we sought to extend examination of the line differences in immune status to T and B cell responsiveness. In addition, we also sought to determine if social experience contributes to line differences in immune responsiveness. A cosibial design was used to examine whether single vs group housing modified the magnitude of line differences in immune status. Compared to aggressive (NC900) mice, nonaggressive (NC100) mice had significantly lower T cell proliferative responses to concanavalin A, lower IL-2 and gamma-interferon production, as well as significantly lower NK activity. Of the various measures of cellular immune responsiveness, housing condition was found to have a significant effect only on NK activity. No significant line by housing interactions were found for any of the immune measures tested. The present data demonstrate that the genetic selection for differences in social behavior is associated with line differences in several parameters of cellular immune responsiveness. These mouse lines provide a valuable research model to examine the association between selection for genetic differences in social behavior and differences in immune responsiveness.
我们最近证明，对ICR小鼠进行社交行为差异（即社交隔离诱导攻击水平高与低）的选择性育种，与肿瘤发生易感性增加和自然杀伤（NK）细胞活性水平降低有关。在本研究中，我们试图将对免疫状态品系差异的研究扩展到T细胞和B细胞反应性。此外，我们还试图确定社交经历是否会导致免疫反应性的品系差异。采用同窝设计来研究单笼饲养与群养是否会改变免疫状态品系差异的程度。与攻击性（NC900）小鼠相比，非攻击性（NC100）小鼠对刀豆蛋白A的T细胞增殖反应显著降低，白细胞介素-2和γ-干扰素产生减少，以及NK活性显著降低。在各种细胞免疫反应性指标中，饲养条件仅对NK活性有显著影响。在所测试的任何免疫指标中，均未发现品系与饲养条件之间的显著交互作用。目前的数据表明，社交行为差异的遗传选择与细胞免疫反应性的几个参数的品系差异有关。这些小鼠品系为研究社交行为遗传差异选择与免疫反应性差异之间的关联提供了一个有价值的研究模型。
