Petitto J M, Lysle D T, Gariepy J L, Clubb P H, Cairns R B, Lewis M H
Department of Psychiatry, University of Florida, Gainesville 32610-0256.
Neuropsychopharmacology. 1993 Jan;8(1):35-43. doi: 10.1038/npp.1993.5.
The hypothesis that certain heritable personality traits would correlate with increased vulnerability to tumor development and reduced natural killer (NK) cell function was tested in mice selectively bred for high and low levels of aggression. This selection program produces a line of mice that fail to exhibit species typical, isolation-induced aggression, but appear socially inhibited in response to a novel partner mouse. All socially inhibited mice developed 3-methylcholanthrene-induced tumors compared with only 44% of the aggressive mice. Basal NK activity was also significantly lower among socially inhibited mice. Conversely, there were no line differences in NK activity between the aggressive line and nonselected, socially isolated mice, consistent with other unidirectional outcomes of this selective breeding program. No significant line differences were present for nonsocial measures of emotional reactivity (e.g., fearfulness) or serum corticosterone levels. These findings support the hypothesis that social "traits" may be related to immune function and tumor susceptibility.
在经过选择性培育以具有高攻击性和低攻击性的小鼠中，对某些可遗传的人格特质与肿瘤发生易感性增加以及自然杀伤（NK）细胞功能降低相关的假说进行了测试。这种选择程序培育出了一组小鼠，它们不会表现出典型的物种隔离诱导的攻击性，但在面对新的伙伴小鼠时表现出社交抑制。与只有44%的攻击性小鼠相比，所有社交抑制的小鼠都发生了3-甲基胆蒽诱导的肿瘤。社交抑制的小鼠的基础NK活性也显著更低。相反，攻击性品系和未选择的、社会隔离的小鼠之间的NK活性没有品系差异，这与该选择性育种程序的其他单向结果一致。在情绪反应的非社交测量指标（如恐惧）或血清皮质酮水平方面，没有显著的品系差异。这些发现支持了社交“特质”可能与免疫功能和肿瘤易感性相关的假说。
