Riis B J
Center for Clinical and Basic Research, Ballerup, Denmark.
Osteoporos Int. 1994;4 Suppl 1:35-7. doi: 10.1007/BF01623433.
Bone strength is closely related to bone mass, and sex differences in bone mass are the main reason for the greater frequency of osteoporotic fractures in elderly women than in men of the same age. Peak bone mass is lower and the subsequent rate of loss is greater in women. It has been debated whether there is a significant bone loss in women before menopause. This has been studied in cross-sectional studies with and without information on menopausal status, and in longitudinal studies following women through the menopause. The present review addresses this issue and discusses important cross-sectional and longitudinal studies on this question. The overall conclusion is that there probably is a minor premenopausal trabecular bone loss which can be found to be of statistical significance where many individuals are included in the study and very precise methods are used, but it is of a magnitude which probably is of no clinical significance.
骨强度与骨量密切相关，骨量的性别差异是老年女性骨质疏松性骨折发生率高于同龄男性的主要原因。女性的峰值骨量较低，且随后的骨量丢失率更高。绝经前女性是否存在显著的骨质流失一直存在争议。这一问题已在有或无绝经状态信息的横断面研究以及跟踪女性度过更年期的纵向研究中进行了探讨。本综述阐述了这一问题，并讨论了关于该问题的重要横断面研究和纵向研究。总体结论是，绝经前可能存在轻微的小梁骨丢失，在纳入众多个体且使用非常精确方法的研究中，这种丢失具有统计学意义，但从程度上讲，可能并无临床意义。
