Olinescu R, Hertoghe J, Săvoiu D, Mătăchescu C, Niţă S
Clinical Hospital Fundeni, Bucharest.
Rom J Intern Med. 1994 Jan-Mar;32(1):37-46.
Steroid hormones, testosterone and estrone may modify the in vitro chemiluminescence (CL) produced by polymorphonuclear leukocytes (PMNL) during phagocytosis. These changes (increases or decreases) depended on the age and health condition of the donor, but not on sex. Generally, these steroid hormones increase the PMNL CL emission at concentrations lower than 10(-5) M, but decrease it at higher levels. In an acellular system, using the same CL technique, these hormones exhibit an opposite effect, by increasing the emission at higher concentrations. As the PMNL induced CL emission is a membrane-dependent process, strongly related to phagocytosis, the action of steroid hormones seems to be due to the receptors on the surface of leukocytes. In both systems, cellular and acellular, the effect of steroid hormones on the CL emission also depends on the concentration of hydrogen peroxide added or released during phagocytosis. The modulatory action of steroid hormones on phagocytosis may occur in certain conditions, such as infections diseases and hormone disturbances in the course of which there occurs a significant release of oxygen free radicals, concomitantly with variations of the levels of steroid hormones.
类固醇激素、睾酮和雌酮可能会改变多形核白细胞（PMNL）在吞噬过程中产生的体外化学发光（CL）。这些变化（增加或减少）取决于供体的年龄和健康状况，而与性别无关。一般来说，这些类固醇激素在浓度低于10^(-5) M时会增加PMNL的CL发射，但在较高浓度时会降低。在无细胞系统中，使用相同的CL技术，这些激素表现出相反的效果，即在较高浓度时增加发射。由于PMNL诱导的CL发射是一个依赖膜的过程，与吞噬作用密切相关，类固醇激素的作用似乎是由于白细胞表面的受体。在细胞和无细胞这两个系统中，类固醇激素对CL发射的影响也取决于吞噬过程中添加或释放的过氧化氢浓度。类固醇激素对吞噬作用的调节作用可能在某些情况下发生，如感染性疾病和激素紊乱，在此过程中会伴随着类固醇激素水平的变化而大量释放氧自由基。
