质粒介导的红霉素耐药性：粪链球菌和化脓性链球菌菌株在质粒同源性及耐药诱导性方面的比较
Plasmid-determined resistance to erythromycin: comparison of strains of streptococcus faecalis and streptococcus pyogenes with regard to plasmid hmology and resistance inducibility.
作者信息
Yag Y, Franke A E, Clewell D B
出版信息
Antimicrob Agents Chemother. 1975 Jun;7(6):871-3. doi: 10.1128/AAC.7.6.871.
Abstract
Streptococcus faecalis strains DS-5 and Streptococcus pyogenes strain AC-1 both have a 17 million dalton plasmid that determines resistance to erythromycin, lincomycin, and vernamycin B(alpha). The results of deoxyribonucleic acid-deoxyribonucleic acid hybridization experiments indicate that the two plasmids are about 95% homologous. It was also shown that erythromycin resistance is inducible in AC-1 and constitutive in DS-5.
摘要
粪肠球菌菌株DS - 5和化脓性链球菌菌株AC - 1都有一个1700万道尔顿的质粒，该质粒决定了对红霉素、林可霉素和维纳霉素B（α）的抗性。脱氧核糖核酸-脱氧核糖核酸杂交实验结果表明，这两种质粒约95%同源。还表明，红霉素抗性在AC - 1中是可诱导的，而在DS - 5中是组成型的。
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