Brocke S, Veromaa T, Weissman I L, Gijbels K, Steinman L
Dept of Neurology and Neurological Sciences, Stanford University Medical Center, CA 94305.
Trends Microbiol. 1994 Jul;2(7):250-4. doi: 10.1016/0966-842x(94)90630-0.
The association of infection with autoimmune diseases is enigmatic, partly because cause and effect are difficult to establish in chronic diseases. Microorganisms might initiate multiple sclerosis and trigger relapses of disease. Superantigens might be involved in autoimmunity through the (re)activation of T cells, including autoreactive cells, expressing certain T cell receptor beta chain variable regions.
感染与自身免疫性疾病之间的关联尚不清楚，部分原因是在慢性疾病中很难确定因果关系。微生物可能引发多发性硬化症并触发疾病复发。超抗原可能通过激活包括自身反应性细胞在内的表达某些T细胞受体β链可变区的T细胞而参与自身免疫。
