Antibody neutralization of picornaviruses: can fever help?
作者信息
Boeyé A, Delaet I, Brioen P
机构信息
Dept of Microbiology and Hygiene, Vrije Universiteit Brussel, Belgium.
出版信息
Trends Microbiol. 1994 Jul;2(7):255-7. doi: 10.1016/0966-842x(94)90631-9.
PMID:8081653
Abstract
Binding of bivalent antibody can neutralize picornaviruses by a variety of mechanisms. Some monoclonal antibodies can irreversibly neutralize the virus at temperatures that are higher than physiological by disrupting the virion, leading to ejection of the RNA. Fever may enhance this process in vivo, confirming the popular belief in the virtues of fever.
摘要
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