蛋白激酶C抑制剂；K252c相关化合物的构效关系

Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds.

作者信息

Fabre S, Prudhomme M, Rapp M

机构信息

Université Blaise Pascal, Laboratoire de Chimie Organique Biologique, URA 485, Aubière, France.

出版信息

Bioorg Med Chem. 1993 Sep;1(3):193-6. doi: 10.1016/s0968-0896(00)82121-5.

DOI:10.1016/s0968-0896(00)82121-5

Abstract

K252c-related compounds were synthesized with different framework flexibilities and different functions (imide, amide and amide-alcohol) on the non-indolic heterocycle. The inhibitory activities towards protein kinase C and protein kinase A are compared.

摘要

合成了具有不同骨架柔韧性以及在非吲哚杂环上具有不同功能（酰亚胺、酰胺和酰胺醇）的K252c相关化合物。比较了它们对蛋白激酶C和蛋白激酶A的抑制活性。

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