Furer M, Hartloper V, Wilkins J, Nath A
Department of Surgery, University of Manitoba, Winnipeg, Canada.
Cell Adhes Commun. 1993 Dec;1(3):223-37. doi: 10.3109/15419069309097256.
Astrocytes have been observed to contain intact, viable lymphocytes within their cytoplasm (emperipolesis) in multiple sclerosis plaques and some brain tumors. This study characterizes the adhesive, emperipoletic and phagocytic properties of glial cells in culture. Human fetal and adult astrocytes engaged in adhesion and emperipolesis of lymphocytes. Emperipolesis, and not adhesion, was temperature- and cation-dependent. The CD8 and MHC Class I antigens played a role in emperipolesis. Lymphocytes most often remained viable within the cytoplasm of astrocytes but occasionally underwent lysis or caused disruption of the astrocyte intermediate filaments. The phenomenon of emperipolesis is distinct from phagocytosis, since microglia showed prominent phagocytic properties but did not engage in emperipolesis. Conversely, astrocytes were efficient emperipolites and rarely demonstrated phagocytic properties.
在多发性硬化斑块和一些脑肿瘤中，已观察到星形胶质细胞的细胞质内含有完整、有活力的淋巴细胞（淋巴细胞穿入现象）。本研究描述了培养的神经胶质细胞的黏附、淋巴细胞穿入及吞噬特性。人胎儿和成人星形胶质细胞可参与淋巴细胞的黏附和淋巴细胞穿入。淋巴细胞穿入而非黏附，依赖于温度和阳离子。CD8和MHC I类抗原在淋巴细胞穿入中发挥作用。淋巴细胞大多在星形胶质细胞的细胞质内保持存活，但偶尔会发生溶解或导致星形胶质细胞中间丝的破坏。淋巴细胞穿入现象与吞噬作用不同，因为小胶质细胞表现出显著的吞噬特性，但不参与淋巴细胞穿入。相反，星形胶质细胞是有效的淋巴细胞穿入细胞，很少表现出吞噬特性。
