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[刺激前连合、杏仁外侧核、终纹床核和下丘脑外侧区对内脏痛的抑制作用]

[The inhibitory effects of stimulating AC, AL, BNST and AHL on visceral pain].

作者信息

Sha L, Huang P, Ding W, Teng G

机构信息

Department of Neurophysiology, China Medical University, Shenyang.

出版信息

Zhen Ci Yan Jiu. 1993;18(1):37-43.

PMID:8082279
Abstract

We took the unit discharges of the neurons in the posterior group of thalamic nuclei (PO) caused by stimulating the great splanchnic nerve (GSN) as an indicator of visceral pain. We searched for the effects of electrical stimulating central nucleus of amygdala (AC), lateral nucleus of amygdala (AL), bed nucleus of striae terminalis (BNST) and lateral area of hypothalmus (AHL) on unit discharges of PO and the relationship among these nucleuses. The result indicated that the inhibitory effects were strongest with stimulating AC, the next was with stimulating AHL, then BNST and AL. The inhibitory percentages were 85.7% (AC), 62.9% (AHL), 53.1% (BNST) and 54.2% (AL) respectively. The inhibitory effects of stimulating AC couldn't be canceled by injecting naloxone intravenously. AC may be more important for the antinociceptive system than AL, BNST and AHL. There was no relationship between AC and BNST on the inhibition of unit discharges. The inhibitory effects of stimulating AL may be related to AC.

摘要

我们将刺激内脏大神经(GSN)所引起的丘脑后核群(PO)中神经元的单位放电作为内脏痛的指标。我们研究了电刺激杏仁核中央核(AC)、杏仁核外侧核(AL)、终纹床核(BNST)和下丘脑外侧区(AHL)对PO单位放电的影响以及这些核团之间的关系。结果表明,刺激AC时抑制作用最强,其次是刺激AHL,然后是BNST和AL。抑制率分别为85.7%(AC)、62.9%(AHL)、53.1%(BNST)和54.2%(AL)。静脉注射纳洛酮不能消除刺激AC的抑制作用。AC对抗伤害感受系统可能比AL、BNST和AHL更重要。在抑制单位放电方面,AC与BNST之间没有关系。刺激AL的抑制作用可能与AC有关。

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