Weichselbaum R R, Hallahan D, Fuks Z, Kufe D
University of Chicago, Department of Radiation and Cellular Oncology, IL.
Int J Radiat Oncol Biol Phys. 1994 Aug 30;30(1):229-34. doi: 10.1016/0360-3016(94)90539-8.
Recent studies have demonstrated that the early response genes c-jun, Egr-1, c-fos, and NF kappa B are induced following exposure of mammalian cells to ionizing radiation. We propose that the products of these early response genes regulate downstream genes that are important in the adaptation of cells and tissues to radiation-induced stress. Potential downstream targets include cytokine and growth factor genes as well as deoxyribonucleic acid (DNA) repair genes. Early response gene products may also regulate cell cycle progression following cellular x-irradiation. Signal transduction pathways that allow cells to adapt to radiation may provide molecular targets to modify tumor and normal responses to radiotherapy.
最近的研究表明，哺乳动物细胞暴露于电离辐射后，早期反应基因c-jun、Egr-1、c-fos和NF-κB会被诱导。我们提出，这些早期反应基因的产物调节下游基因，这些下游基因在细胞和组织适应辐射诱导的应激中起重要作用。潜在的下游靶点包括细胞因子和生长因子基因以及脱氧核糖核酸（DNA）修复基因。早期反应基因产物还可能在细胞X线照射后调节细胞周期进程。使细胞适应辐射的信号转导途径可能提供分子靶点，以改变肿瘤和正常组织对放疗的反应。
