Chiou G C, Li B H, Wang M S
Institute of Ocular Pharmacology, Texas A&M University Health Science Center, College Station.
J Ocul Pharmacol. 1994 Summer;10(2):493-8. doi: 10.1089/jop.1994.10.493.
The b-wave of electroretinogram (ERG) was used as an indicator of the retinal function in this research to study the facilitation of retinal function recovery by some natural products isolated from medicinal plants. The retinal ischemia was induced by occlusion of the central retinal artery. It was found that the recovery of b-waves was limited to approximately 30-37% in control animals, whereas the b-wave recovery was doubled by natural products, including scoparone, corylifolinin and EGCG (epigallocatechin-3-0-gallate). Lespedeza flavanone A had biphasic action by suppressing the b-wave recovery below control level initially, then enhancing the b-wave recovery over the control rate later. These results indicate that some natural products could be used for the treatment of ischemic retinopathy.
在本研究中，视网膜电图（ERG）的b波被用作视网膜功能的指标，以研究从药用植物中分离出的一些天然产物对视网膜功能恢复的促进作用。通过阻塞视网膜中央动脉诱导视网膜缺血。结果发现，在对照动物中，b波的恢复仅限于约30-37%，而包括滨蒿内酯、紫花前胡苷元和表没食子儿没食子酸酯（EGCG）在内的天然产物使b波的恢复增加了一倍。胡枝子黄烷酮A具有双相作用，最初将b波恢复抑制到对照水平以下，随后又使b波恢复超过对照率。这些结果表明，一些天然产物可用于治疗缺血性视网膜病变。
