Liu S X, Kapingu M C, Wang M S, Chiou G C
Institute of Ocular Pharmacology, Texas A&M University College of Medicine, College Station, USA.
J Ocul Pharmacol Ther. 1997 Feb;13(1):69-79. doi: 10.1089/jop.1997.13.69.
Ischemic retinopathy is a difficult disease to treat, although numerous drugs have been tried in the clinics. Coumarin was one of those tried as an anti-coagulant with a marginal efficacy. In this study, 15 coumarin derivatives were studied on the b-wave recovery in electroretinogram which is an indicator of the functional recovery of retina after ischemic insult. It was found that when positions 6, 7 and 8 were occupied by various functional groups, the b-wave recovery could be markedly enhanced. On the other hand, single occupation of position 3 with any functional group would cause damaging effects to the anti-ischemic activity. It is concluded that some coumarin derivatives with two or all of these positions at 6, 7 and 8 occupied by certain functional groups could result in useful drugs for the treatment of ischemic retinopathy.
缺血性视网膜病是一种难以治疗的疾病，尽管临床上已经尝试了许多药物。香豆素是其中一种作为抗凝血剂试用但疗效甚微的药物。在本研究中，对15种香豆素衍生物进行了视网膜电图b波恢复情况的研究，b波恢复情况是缺血性损伤后视网膜功能恢复的一个指标。研究发现，当6、7和8位被各种官能团占据时，b波恢复可显著增强。另一方面，3位被任何官能团单独占据都会对抗缺血活性产生破坏作用。结论是，某些6、7和8位中的两个或全部被特定官能团占据的香豆素衍生物可能会成为治疗缺血性视网膜病的有效药物。
