Chiou G C, Li B H
Institute of Ocular Pharmacology, Texas A&M University College of Medicine, College Station.
J Ocul Pharmacol. 1993 Summer;9(2):179-85. doi: 10.1089/jop.1993.9.179.
Retinal ischemia was developed by occlusion of the central retinal artery for 30 minutes. The artery was reperfused thereafter, and the recovery of the b-wave amplitude was determined as an indication of the recovery of retinal function after ischemia. Following ischemia, it was found that dopamine antagonists, including chlofluperol, metoclopramide, trifluperol and droperidol, increased in b-wave amplitude recovery significantly over the control b-wave recovery. Similar effects were observed with haloperidol and loxapine, but to a lesser extent. The results correlated well with the improvement of retinal blood flow by these dopamine antagonists (4,5). Neither floropipamide, a dopamine antagonist, nor bromocriptine, a dopamine agonist, affected the b-wave recovery after ischemia. These results also correlate well with the inability of these agents to increase the retinal blood flow measured by the microsphere technique (4,5). These findings suggest that most of the dopamine antagonists, with the exception of floropipamide, could be used for the treatment and/or prevention of ischemic retinopathy.
通过阻塞视网膜中央动脉30分钟来诱导视网膜缺血。此后使动脉再灌注，并将b波振幅的恢复作为缺血后视网膜功能恢复的指标来测定。缺血后发现，包括氯氟哌醇、甲氧氯普胺、三氟哌醇和氟哌利多在内的多巴胺拮抗剂，在b波振幅恢复方面比对照b波恢复显著增加。氟哌啶醇和洛沙平也观察到类似效果，但程度较轻。这些结果与这些多巴胺拮抗剂对视网膜血流的改善情况密切相关（4,5）。多巴胺拮抗剂氟罗哌酰胺和多巴胺激动剂溴隐亭均未影响缺血后的b波恢复。这些结果也与这些药物无法通过微球技术增加所测量的视网膜血流密切相关（4,5）。这些发现表明，除氟罗哌酰胺外，大多数多巴胺拮抗剂可用于治疗和/或预防缺血性视网膜病变。
