Zebrowski E J, Pylypas S P, Odlum O, Johnson R B
Department of Oral Biology, Faculty of Dentistry, University of Manitoba, Winnipeg.
J Periodontol. 1994 Jun;65(6):565-7. doi: 10.1902/jop.1994.65.6.565.
Cyclosporine and nifedipine therapy produces gingival overgrowth in many patients. Neither the mechanism underlying this undesirable side effect nor the possibility of synergism between these drugs is known, although many renal transplant patients receive both drugs. This study compared the rates of 3H-glucosamine utilization by three groups of fibroblasts: untreated gingival fibroblasts, fibroblasts from gingival overgrowth tissue of a patient receiving both cyclosporine and nifedipine, and normal gingival fibroblasts exposed to cyclosporine-A in vitro. Significant differences in the rates of deposition of 3H-glucosamine into the extracellular matrix by each group of gingival fibroblasts were demonstrated, suggesting that increased rates of deposition of proteoglycans into the gingival extracellular matrix by fibroblasts should be further investigated as a biologic mechanism for gingival overgrowth.
环孢素和硝苯地平疗法会使许多患者出现牙龈增生。尽管许多肾移植患者同时服用这两种药物，但这种不良副作用的潜在机制以及这两种药物之间协同作用的可能性均尚不明确。本研究比较了三组成纤维细胞对³H-葡糖胺的利用速率：未处理的牙龈成纤维细胞、来自一名同时接受环孢素和硝苯地平治疗患者的牙龈增生组织的成纤维细胞，以及体外暴露于环孢素A的正常牙龈成纤维细胞。结果表明，每组牙龈成纤维细胞将³H-葡糖胺沉积到细胞外基质中的速率存在显著差异，这表明成纤维细胞将蛋白聚糖沉积到牙龈细胞外基质中的速率增加作为牙龈增生的生物学机制值得进一步研究。
