Bellati U, Liberati M
Clinica Ostetrica e Ginecologica, Università degli Studi, G. D'Annunzi, Cheti.
Minerva Med. 1994 Jun;85(6):327-32.
Two matched groups of postmenopausal patients were treated respectively with calcitonin or calcitonin and an arginine-lysine-glycerophosphoric acid-lactose association. The rationale underlying this therapy took the form of data in the literature which indicated an action of these amino acids and lactose on calcium absorption and on the metabolism of protein components in the skeletal structure. The following tests were performed: mineralometric evaluation, evaluation of painful symptoms and intake of pain-relieving drugs, serum levels of calcium, phosphorus, alkaline phosphatase, osteocalcin, parathormone, and calciuria and hydroxyproline. These parameters were assayed at the beginning and end of treatment which lasted six months. The results, or in other words the comparison between the two groups, basal or after treatment, and the values recorded before and after treatment in each group, enable the authors to affirm that the administration of the arginine-lysine-glycerophosphoric acid-lactose association leads to an increase in bone density and plasma osteocalcin, a reduction in painful symptoms and analgesic intake, and a reduction in the serum levels of parathromone and hydroxyproline. Data reported in the literature support the conclusion that the results obtained are the consequence of an improved intestinal absorption calcium. It is highly probable that the protein components of the association administered, arginine-lysine-glycerophosphoric acid-lactose, also exercise a direct action on osteoblasts and on the metabolism of bone matrix protein components.
将两组匹配的绝经后患者分别用降钙素或降钙素与精氨酸 - 赖氨酸 - 甘油磷酸 - 乳糖组合进行治疗。这种治疗的基本原理源于文献中的数据，这些数据表明这些氨基酸和乳糖对钙吸收以及骨骼结构中蛋白质成分的代谢有作用。进行了以下测试：矿物质评估、疼痛症状评估和止痛药物摄入量、血清钙、磷、碱性磷酸酶、骨钙素、甲状旁腺激素水平，以及尿钙和羟脯氨酸。这些参数在为期六个月的治疗开始和结束时进行测定。结果，换句话说，两组之间、治疗前后的比较以及每组治疗前后记录的值，使作者能够肯定，给予精氨酸 - 赖氨酸 - 甘油磷酸 - 乳糖组合会导致骨密度和血浆骨钙素增加，疼痛症状和止痛药物摄入量减少，以及血清甲状旁腺激素和羟脯氨酸水平降低。文献报道的数据支持这样的结论，即所获得的结果是肠道钙吸收改善的结果。很可能所给予组合中的蛋白质成分，即精氨酸 - 赖氨酸 - 甘油磷酸 - 乳糖，也对成骨细胞和骨基质蛋白质成分的代谢有直接作用。
