Fini M, Giardino R, Nicoli Aldini N, Martini L, Rocca M, Bertoni F, Capelli S, Cantelli Forti G, Sapone A, Rossetti A, Morrone G, Giavaresi G
Cattedra di Fisiopatologia Chirurgica, Università di Bologna.
Ann Ital Chir. 1996 Jan-Feb;67(1):77-82; discussion 82-3.
L-arginine and L-lysine are essential amino acids which seem to possess some properties able to influence bone fractures healing. In fact, they seem to be involved not only in the increase of intestinal calcium adsorption but also in collagen synthesis, in insulin and growth hormone secretion and in osteoblastic activation. So, an experimental in vivo model was carried out by using 50 adult rabbits which, under general anaesthesia, were submitted to an osteotomy of the left fibula. Animals were divided into 5 groups and were daily treated with a mixture of lactose, L-arginine and L-lysine or with the only lactose (control group) at the same dosage as recommended for humans. They were sacrificed after 15, 30, 40, 50 and 60 days for radiological and histological studies. The results of the study showed that the pharmacological mixture containing L-arginine and L-lysine accelerates and ameliorates the healing processes and this positive effect was particularly evident from the 30th day after the osteotomy. We think that these results are linked not only to calcium metabolism but also to different biological properties which positively contribute to a good healing of bone fractures.
L-精氨酸和L-赖氨酸是必需氨基酸，它们似乎具有一些能够影响骨折愈合的特性。事实上，它们似乎不仅参与肠道对钙的吸收增加，还参与胶原蛋白合成、胰岛素和生长激素分泌以及成骨细胞活化。因此，通过使用50只成年兔子进行了一项体内实验模型，这些兔子在全身麻醉下接受了左腓骨截骨术。将动物分为5组，每天用乳糖、L-精氨酸和L-赖氨酸的混合物或仅用乳糖（对照组）进行治疗，剂量与推荐给人类的相同。在15、30、40、50和60天后将它们处死以进行放射学和组织学研究。研究结果表明，含有L-精氨酸和L-赖氨酸的药物混合物可加速和改善愈合过程，并且这种积极作用在截骨术后第30天尤为明显。我们认为这些结果不仅与钙代谢有关，还与不同的生物学特性有关，这些特性对骨折的良好愈合有积极贡献。
