Testosterone modulates mesolimbic dopaminergic activity in male rats.
作者信息
Hernandez L, Gonzalez L, Murzi E, Páez X, Gottberg E, Baptista T
机构信息
Laboratory of Behavioral Physiology, Los Andes University, Venezuela.
出版信息
Neurosci Lett. 1994 Apr 25;171(1-2):172-4. doi: 10.1016/0304-3940(94)90632-7.
PMID:8084484
Abstract
Male rats were castrated before puberty. When they were adult, the activity of their mesolimbic dopamine system was tested by ventral striatum microdialysis. Amphetamine injections increased dopamine more in castrated rats than in normal rats. This exaggerated response was attenuated by testosterone replacement therapy. The mechanism by which androgens modulate the activity of the mesolimbic dopamine system is discussed.
摘要
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