Kobayashi T, Abe K, Saito H, Nishiyama N
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Neurosci Lett. 1994 May 19;172(1-2):147-50. doi: 10.1016/0304-3940(94)90683-1.
alpha 1-Antichymotrypsin (ACT) and beta-amyloid have been reported to be present in senile plaques. We investigated the combination effects of ACT and a novel synthetic beta-amyloid peptide, on rat primary cultured brain neurons. ACT had no effect in high density culture and decreased the number of surviving neurons in low density cell culture. Combination of ACT with beta 25-40 did not affect the toxicity of beta 25-40 in high and low density culture.
据报道，α1抗糜蛋白酶（ACT）和β淀粉样蛋白存在于老年斑中。我们研究了ACT与一种新型合成β淀粉样肽对大鼠原代培养脑神经元的联合作用。ACT在高密度培养中没有作用，而在低密度细胞培养中会减少存活神经元的数量。ACT与β25-40联合使用在高密度和低密度培养中均不影响β25-40的毒性。
