Cutrera R A, Ouarour A, Pévet P
URA-CNRS 1332, Neurobiologie des Fonctions Rythmiques et Saisonnières, Université Louis Pasteur, Strasbourg, France.
Neurosci Lett. 1994 May 19;172(1-2):27-30. doi: 10.1016/0304-3940(94)90654-8.
Our findings show that administration of the 5-HT1A receptor agonist 8-OH-DPAT (8-hydroxy-2-[di-n-propylamino] tetralin) was able to induce significant phase-advances 4 h before onset of hamster locomotor activity under constant darkness. All other non-photic treatments applied such as melatonin, dimethyl sulphoxide, Ringer, saline or enforced wheel-running failed to induce any significant phase-advances. Similar results were obtained in pinealectomized animals. In constant light (LL), all treatments produced phase-advances. These results show that: (1) LL seems to be an inappropriate constant condition to study the chronobiological effect of drugs or other non-photic stimuli; (2) the endogenous circadian pacemaker (SCN) can be affected specifically by 8-OH-DPAT.
我们的研究结果表明，在持续黑暗条件下，于仓鼠运动活动开始前4小时给予5-羟色胺1A受体激动剂8-羟基-2-（二正丙基氨基）四氢化萘（8-OH-DPAT）能够诱导显著的相位提前。所应用的所有其他非光刺激处理，如褪黑素、二甲基亚砜、林格液、生理盐水或强制跑步，均未能诱导任何显著的相位提前。在松果体切除的动物中也获得了类似结果。在持续光照（LL）条件下，所有处理均产生相位提前。这些结果表明：（1）持续光照似乎是研究药物或其他非光刺激的生物钟效应的不合适的恒定条件；（2）内源性昼夜节律起搏器（视交叉上核）可受到8-OH-DPAT的特异性影响。
