Brosschot J F, Benschop R J, Godaert G L, Olff M, De Smet M, Heijnen C J, Ballieux R E
Department of Clinical and Health Psychology, Faculty of Social Sciences, University of Utrecht, The Netherlands.
Psychosom Med. 1994 May-Jun;56(3):216-24. doi: 10.1097/00006842-199405000-00007.
This study investigated the effects of self-reported life stress and locus of control on reactivity of several immune parameters to a mild and short-lasting interpersonal stressor. Subjects were 86 male teachers aged 24 to 55 years. Immune reactivity was defined as changes in numbers of monocytes. T-lymphocytes and subsets, HLA-DR+ cells, and NK cells as well as changes in (in vitro) proliferative responses of peripheral blood lymphocytes to the antigens PHA and PWM. Multiple regression analysis was used to study the interaction effects of life stress and locus of control by experimental condition on immune reactivity. Life stress, but not locus of control, influences reactivity of the immunological parameters to the stressor. In particular, high numbers of daily hassles were associated with stressor-induced decreases in numbers of T cells and NK cells in peripheral blood. On the other hand, numbers of HLA-DR+ cells in high life stress scorers decreased only slightly during the stressor, whereas they increased in the control condition. The findings suggest that accumulated life stress is related to reactivity of immunological parameters to subsequent experimental stress. Possible physiological explanations and implications of these effects are discussed.
本研究调查了自我报告的生活压力和控制点对几种免疫参数对轻度和短期人际应激源反应性的影响。研究对象为86名年龄在24至55岁之间的男性教师。免疫反应性定义为单核细胞、T淋巴细胞及其亚群、HLA-DR+细胞和NK细胞数量的变化，以及外周血淋巴细胞对抗原PHA和PWM的（体外）增殖反应的变化。采用多元回归分析来研究生活压力和控制点在实验条件下对免疫反应性的交互作用。生活压力而非控制点会影响免疫参数对应激源的反应性。具体而言，大量的日常琐事与应激源引起的外周血T细胞和NK细胞数量减少有关。另一方面，高生活压力得分者的HLA-DR+细胞数量在应激源期间仅略有下降，而在对照条件下则有所增加。研究结果表明，累积的生活压力与免疫参数对后续实验应激的反应性有关。文中讨论了这些效应可能的生理学解释及意义。
