Pueschel S M, Werner J C
Rhode Island Hospital.
Res Dev Disabil. 1994 Mar-Apr;15(2):91-7. doi: 10.1016/0891-4222(94)90015-9.
This study was designed to determine the prevalence of mitral valve prolapse and aortic insufficiency in home-reared, young persons with Down syndrome. Of the 36 individuals (ages 20-32 years) enrolled in this study, 20 had abnormal echocardiographic findings. Thirteen patients had mitral valve prolapse, 3 had both mitral valve prolapse and aortic insufficiency, 2 had only aortic insufficiency, and 2 had other mitral valve disorders. In 14 of the 16 patients with mitral valve prolapse, a midsystolic click was heard. Theories of the pathogenesis and possible complications of mitral valve prolapse and its relationship to exercise and sport activities are discussed.
本研究旨在确定在家抚养的唐氏综合征青年人群中二尖瓣脱垂和主动脉瓣关闭不全的患病率。在本研究纳入的36名个体（年龄20 - 32岁）中，20人有异常超声心动图表现。13例患者有二尖瓣脱垂，3例既有二尖瓣脱垂又有主动脉瓣关闭不全，2例仅有主动脉瓣关闭不全，2例有其他二尖瓣疾病。在16例二尖瓣脱垂患者中的14例可闻及收缩中期喀喇音。本文讨论了二尖瓣脱垂的发病机制理论、可能的并发症及其与运动和体育活动的关系。
