Griaznova N S, Beliavskaia I V, Afonin V I, Zinchenko E Ia, Sazykin Iu O, Navashin S M
Antibiot Khimioter. 1993 Dec;38(12):3-6.
Beta-lactam antibiotics (some penicillins and cephalosporins), a fluorquinolone (pefloxacin) and cephalosporin conjugates with fluorquinolones were liposome-encapsulated by the method of detergent dialysis. Under the experimental conditions the entrapment of the beta-lactams and pefloxacin to liposomes did not exceed 20 and 12.5 per cent of the initial quantity respectively. The liposome entrapment of the cephalosporin conjugates with fluorquinolones was much higher. The entrapment of the cefotaxime conjugate with ciprofloxacin amounted to 40 per cent and that of the cefamandol conjugate with pefloxacin amounted to 95 per cent of the initial quantity.
β-内酰胺类抗生素（某些青霉素和头孢菌素）、一种氟喹诺酮类药物（培氟沙星）以及头孢菌素与氟喹诺酮类药物的缀合物通过去污剂透析法被脂质体包封。在实验条件下，β-内酰胺类药物和培氟沙星被包封到脂质体中的量分别不超过初始量的20%和12.5%。头孢菌素与氟喹诺酮类药物的缀合物被脂质体包封的量要高得多。头孢噻肟与环丙沙星的缀合物的包封率达初始量的40%，头孢孟多与培氟沙星的缀合物的包封率达初始量的95%。
