Rook G A, Hernandez-Pando R, Lightman S L
Dept of School, London, UK.
Immunol Today. 1994 Jul;15(7):301-3. doi: 10.1016/0167-5699(94)90075-2.
There is much interest in the factors that control the cytokine profile of T-helper (Th) lymphocytes, and attention has focused on feedback from the cytokines themselves. In general, Th1 cytokines promote Th1 activity and inhibit Th2 activity, and vice versa. Both Th1 and Th2 responses should therefore be stable. However, in vivo, many responses start predominantly as Th1 and then shift to Th2. Why do they do this? As discussed here, an important influence on this shift that has been largely ignored in in vitro work is the endocrine system.
人们对控制辅助性T（Th）淋巴细胞细胞因子谱的因素非常感兴趣，并且注意力集中在细胞因子自身的反馈上。一般来说，Th1细胞因子促进Th1活性并抑制Th2活性，反之亦然。因此，Th1和Th2反应都应该是稳定的。然而，在体内，许多反应最初主要是Th1型，然后转变为Th2型。它们为什么会这样呢？如下所述，内分泌系统对这种转变有重要影响，而这在体外研究中很大程度上被忽视了。
