Warner M R, Warner R L
J Natl Cancer Inst. 1975 Aug;55(2):289-98.
Mice exposed to estrogens as neonates developed more mammary dysplasias and had different morphologic types of dysplasias than did normal animals when both groups were exposed to a carcinogen: 1) before puberty, 2) during active mammary growth, 3) or at 6 months of age (the time when spontaneous dysplasias begin to appear in normal animals). The relative percentages of various morphologic types of dysplasias differed in hosts that received different treatments. The significance for subsequent patterns of mammary disease caused by exposure of neonates to 17beta-estradiol was discussed.
当新生小鼠和正常动物都接触致癌物时，新生期接触雌激素的小鼠比正常动物发生更多的乳腺发育异常，且发育异常的形态学类型也不同：1）青春期前；2）乳腺活跃生长期间；3）或6月龄时（正常动物开始出现自发性发育异常的时间）。接受不同处理的宿主中，各种形态学类型发育异常的相对百分比有所不同。文中讨论了新生期接触17β-雌二醇对后续乳腺疾病模式的影响。
